The Effect of Flaxseed Extract on the Hepatic Tissue Injury in Stretozotocin-induced Diabetic Rat

2016 • 146 sayfa • EN

Yazan Ahmed Nuri Ahmed Abired

Prescribed medications used to treat diabetes do not adequately inhibit the development of its associated complications, furthermore, they may cause different side effects. Hence, there is a demand for alternative therapies to manage diabetes and its associated complications. This study aimed to evaluate the hepatoprotective effects of flaxseed extract in streptozotocin-induced diabetic rats. Diabetes mellitus was induced in Sprague-Dawley rats using a single injection of streptozotocin (60 mg/kg, intraperitoneally). The rats were divided into five groups of 8 animals each: Group NC, normal control rats; Group NF, normal rats treated with flaxseed extract (400 mg/kg); Group DC, diabetic control rats; Group DG, diabetic rats treated with glibenclamide (0.6 mg/kg); Group DF, diabetic rats treated with flaxseed extract (400 mg/kg); for 4 weeks. Body weight, liver relative weight, blood glucose level, liver enzymes and histopathological changes were determined in all experimental rats. Results showed a significantly increased relative liver weight, blood glucose, AST, ALT, GGT, ALP, and LDH levels, and decreased body weight, total protein, albumin, and globulin levels in DC group comparing to NC group (p